Journal: International Journal of Molecular Sciences
Article Title: Reorganization of Metabolism during Cardiomyogenesis Implies Time-Specific Signaling Pathway Regulation
doi: 10.3390/ijms22031330
Figure Lengend Snippet: Retinoic acid (RA) synthesis and signaling activation during in vitro cardiac differentiation. ( A ) Comparison of DEGs identified in the RA signaling pathway at the mesoderm (D1 × D4) and cardiac progenitor (D4 × D9) commitment stages. ( B ) Fold change values (log) of the DEGs from the D1 × D4, D4 × D9 and D0 × D15 comparisons. ( C ) Heatmaps representing the gene expression profiles (log2 RPKM values) of DEGs related to RA signaling. Red boxes indicate upregulated genes, while green boxes indicate downregulated genes. Rol: retinol, Ral: retinal. Adapted from Ingenuity Pathway Analysis.
Article Snippet: The heatmaps were generated by GraphPad Prism software Version 7 for Windows (GraphPad Software, San Diego, CA, USA).
Techniques: Activation Assay, In Vitro, Comparison, Gene Expression